May require large amounts in severe cholinesterase inhibitor poisoning. Organophosphate/ carbamate insecticide poisoning and other cholinesterase inhibitors (eg, warfare agents) bradycardia induced by a variety of toxins
Medical centers that might expect to receive large numbers of patients in a single incident should stock larger amounts of antidotes or have an effective and efficient drug sharing/transfer procedure in place to rapidly obtain additional antidotal supplies. For medical centers choosing to stock antidotes, the suggested stocking level is based on the dose needed to treat a single 100 kg patient for 8 hours and for 24 hours.
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